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Some early synthetic cannabinoids have been also used clinically. Nabilone, a first technology artificial THC analog, has long been used as an antiemetic to beat vomiting and nausea considering that 1981.
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PB-22 and 5F-PB-22 have been the very first synthetic cannabinoids to incorporate a quinoline substructure and an ester linkage. These compounds are imagined to are actually synthesized Using the intention of constructing a artificial cannabinoid prodrug, which could improve absorption and confound detection. Ester bonds are simply biodegradable via spontaneous or endogenous, nonspecific esterase hydrolysis, that has been usually used in medicinal chemistry to generate ester prodrugs.
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